New $5.4M grant funds JAX studies of ‘cognitive resilience’ to Alzheimer’s disease

According to recent press release, a new five-year grant totaling $5,382,423 to Jackson Laboratory (JAX) Assistant Professor Catherine Kaczorowski will fund research to explore why some people with a family history of Alzheimer’s disease, and even brain changes associated with the disease, nevertheless manage to maintain their cognitive capabilities. Understanding the genetic factors behind this so-called cognitive resilience could provide targets for treatment and prevention of Alzheimer’s disease. Several genetic mutations have been traced to a rare, early-onset type of Alzheimer’s disease that runs in families and appears in patients as young as 30 years old. With the new grant from the National Institute on Aging, Kaczorowski will study mice carrying these mutations to identify other genetic factors that may overcome the cognitive decline that usually comes with Alzheimer’s disease.

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